If the spectrum shows a lot of peaks independent from their size. It is a drug metabolite of lidocaine local anasthetic. Based on these results, 2,6xylidine is classified as a mutagenic carcinogen according to the eu and ghs criteria cat. In this document studies available for cancer doseresponse assessment are provided. Lidocaine, xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. This oily liquid is colourless when pure, but commercial samples are often yellow. Buy high quality 2, 6 dimethylaniline 87627 from toronto research chemicals inc. Name last modified size parentdir parent directory.
Buy high quality 2,6dimethylaniline hydrochloride 21436986 from toronto research chemicals inc. Its cas number is and its smiles structure is nc1cccccc1c. N,ndimethylaniline dma is an organic chemical compound, a substituted derivative of aniline. Since free 2, 6 dimethylaniline may be formed by intestinal metabolism of 2, 6 dimethylaniline based azo dyes, its absorption into the circulation from the small intestine was studied. A frequently used synonym for 2, 6 xylidine is 2, 6 dimethylaniline. Each step is discussed in more detail in each individual part of the lab along with experimental procedures. The alkaline ph single cell gel electrophoresis scge assay or comet assay was used to evaluate for dna damage induced in bone marrow cells of b6c3f1 mice by four aniline derivatives 2,4 dimethylaniline 2,4xylidine. Chemicalbook provide chemical industry users with 2, 6 dimethyl1nitrobenzene boiling point melting point, 2, 6 dimethyl1nitrobenzene density msds formula use,if you also need to 2, 6 dimethyl1nitrobenzene other information,welcome to contact us. Material safety data sheet secti on 1 2,6dimethylaniline 1 chemical product and company identification msds name. One of the most common mistakes was not to analyze the n ch region correctly to determine what type of compound alkane, alkene, aromatic, or mixed is present.
Alcohols ohstretch usually show a rounded peak in this area. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 09 2016. We are in the business of phenols and xylenols and their derivatives with manufacturing facilities in india. Dimethylaniline undergoes many of the reactions expected for an aniline, being weakly basic and reactive toward electrophiles. It is an important precursor to dyes such as crystal violet preparation and reactions.
Lu wang, glib baryshnikov, dawei li, hans agren, hiroyuki furuta, yongshu xie. Shut off ignition sources and call fire department. Each step is discussed in more detail in each individual part of. Many xylidines are prepared by nitration of a xylene followed by hydrogenation of the nitroaromatic, but this. Based on these results, 2, 6 xylidine is classified as a mutagenic carcinogen according to the eu and ghs criteria cat. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Download hires imagedownload to mspowerpointcite this.
Determination of 2,6dimethylaniline and otoluidine impurities in preparations for local anaesthesia by the hplc method with amperometric detection. Buy high quality 2,6dimethylaniline 87627 from toronto research chemicals inc. In addition, the test substance is listed in the clp regulation no 12722008 on classification, labelling and packaging of substances and mixtures and classified as carcinogen cat. There is also a difference between amine and amides in terms of width and intensity of the peaks. Preparation of lidocaine this twostep synthesis involves the following conversion. It is used in production of some anesthetics and other chemicals. It provides data structure handling for c, portability wrappers, and. Descriptions of the methodology used in the derivations are provided in the appendix.
It was found that 2,4dimethylaniline and 2,4,6trimethylaniline were able to damage dna in the liver cells of the. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine production and reactions. Dntl was established with the main objective of adding greater value to customers products and realize the potential of innovation. Zn3 ethyl2methyloxazolidin5ylidene2,6dimethylaniline 32 is. Pharmacopoeial analytical methods for the determination of these impurities are little sensitive.
When heated to decomposition it emits toxic fumes ofnox. A summary of the derivation of the cancer potency and nsrl are also presented. The promoters have expertise of handling hazardous chemicals. The company is registered with indiamart since 8 years. The 2,6dimethylnitrobenzene is the oxidizing reagent and stannous chloride is used as the reducing reagent in the reaction. The alkaline ph single cell gel electrophoresis scge assay or comet assay was used to evaluate for dna damage induced in bone marrow cells of b6c3f1 mice by four aniline derivatives 2,4dimethylaniline 2,4xylidine. It was found that 2,4 dimethylaniline and 2,4, 6 trimethylaniline were able to damage dna in the liver cells of the. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine. The glib package contains lowlevel libraries useful for providing data. It is used in the production of some anasthetics and other chemicals. Predicted data is generated using the us environmental protection agencys episuite.
The presence of two peaks suggests a primary amine nh 2 while secondary amines show only one peak in this range. Determination of 2,6dimethylaniline and otoluidine. A frequently used synonym for 2,6xylidine is 2,6dimethylaniline. Buy high quality 2, 6 dimethylaniline hydrochloride 2143698 6 from toronto research chemicals inc. It consists of a tertiary amine, featuring dimethylamino group attached to a phenyl group. Some of the mimetyperelated functionality in gio requires the. Import data and price of n n dimethylaniline under hs code. Male wistar rats were instilled with 10 mg 2, 6 dimethylaniline pure in 10 ml phosphatebuffered saline ph 6 into the intestine. Sds of 2,6dimethylaniline, safety data sheets, cas 87627.
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